Prontosan - InnoviceUSA

Prontosan® has sustained activity that inhibits microbial growth after initial exposure.*
For indications such as wound antisepsis and treatment of mucosal infections, where a prolonged contact time for antiseptic treatment is feasible, the following ranking for the investigated antiseptic agents regarding their effective microbiostatic and microbiocidal concentration was set: polyhexanide (PHMB) = octenidine > chlorhexidine > triclosan > PVP – Iodine.*
PHMB has a greater antimicrobial efficacy than chlorhexidine under both clean and dirty conditions. Its antimicrobial effect is not impaired even with high loads of blood or albumin, but exceeds the efficacy of PVP-iodine in situations with high blood load. Most importantly, PHMB was shown to maintain its antibacterial effect in human wound fluid and human tissue.*
Non-cytotoxic with high tissue compatibility/Biocompatibility Index.*
PHMB is supportive to wound healing.*
PHMB is the 1st Choice for: Prevention of SSI, Critically Colonized Wounds, Wounds at Risk of Infection, Decontamination of Acute and Chronic Wounds & for Burns.*
PHMB solution was superior to 1% PVP-I, LR and 4% Hydrogen Peroxide in antisepsis of traumatic wounds requiring surgical intervention.*

Not all claims are approved in the USA

* A. Kramer, Greifswald – Consensus on Wound Antisepsis Update 2018 / Zakopane 201811.Hübner, N-O & Kramer, A. (2010). Review on the Efficacy, Safety and Clinical Applications of Polihexanide, a Modern Wound Antiseptic. Skin pharmacology and physiology. 23 Suppl. 17-27. 10.1159/000318264.

* Hübner, N-O & Kramer, A. (2010). Review on the Efficacy, Safety and Clinical Applications of Polihexanide, a Modern Wound Antiseptic. Skin pharmacology and physiology. 23 Suppl. 17-27. 10.1159/000318264.

* Roth B, Neuenschwander R, Brill F, Wurlitzer F, Wegner C, Assadian O, Kramer A. Effect of antiseptic irrigation on infection rates of traumatic soft tissue wounds: a longitudinal cohort study. 2017

* T. Koburger, N.-O. Hübner, M. Braun, J. Siebert, A. Kramer, Standardized comparison of antiseptic efficacy of triclosan, PVP–iodine, octenidine dihydrochloride, polyhexanide and chlorhexidine digluconate, Journal of Antimicrobial Chemotherapy, Volume 65, Issue 8, August 2010, Pages 1712–1719

* Kaehn, K. Polihexanide: A Safe and Highly Effective Biocide; Skin Pharmacy Physiol 2010; 23(suppl1); 7-16

* Wound Gel X Instructions for Use. Bethelemem, PA. B. Braun: 2017

*Data on file

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